The CCL20 gene is located on chromosome 2q36.3 in a short haplotype block containing no other genes (see ).
1 These data have yet to be replicated in other populations. 1 In a South Korean population, the 1706G→A polymorphism in the CCL20 promoter was strongly associated with susceptibility to UC (p<0.0001). IntroductionRecent data have suggested that variants of the CCL20 gene are associated with susceptibility to ulcerative colitis (UC). GI Unit, Molecular Medicine Centre, University of Edinburgh, UK We confirm the association with HLA‐DRB1*0103 and further demonstrate that this allele may predict disease course.Ġ02 Analysis of CCL20 variants in IBD provides further evidence for genetic heterogeneity in disease susceptibilityĬ. We confirmed the association with DRB1*0103 (14.7% cases v 2.7% controls p = 5.5×10 −9 RR = 3.2) and report the novel association of this allele with time to first surgical event (Log Rank p = 0.002) and time to first “severity event” (resection/diversion ileostomy/Infliximab) (p = 0.001).ĬonclusionsThis study reports the clinical manifestations of isolated colonic CD. 12% of the entire cohort received ⩾1 Infliximab infusion and 19% underwent colonic resection for severe disease (cumulative risk at 2 years, 10.6% 5 years, 17.1% 10 years, 32.8%). Stricturing colonic disease was noted in 10% of patients. 29.4% and 14.0% reported a family history (1st or 2nd degree) of CD and UC respectively. The mean age at diagnosis was 30.7 years. Results136 (10.3%) patients were classified with L2 disease after a median follow up of 10.8 years (range 1.4–39.8). HLA genotyping was performed using PCR‐SSP. Only patients with a normal small bowel enema (70%), ileoscopy alone (30%), or both (20%) were included.
MethodsPatients with L2 disease were identified from a database of 1318 CD patients. (2) To confirm the association with HLA‐DRB1*0103, reported in smaller cohorts, and to investigate its role in predicting disease course and need for surgery. Little is known about the epidemiology and natural history of isolated CD of the colon (Montreal Classification L2) because most studies have not accurately distinguished L2 from 元 disease (ileo‐caecal).Īims(1) To describe the clinical features and natural history of isolated colonic CD in a rigorously characterised patient cohort. Departments of 1Gastroenterology, 2Colorectal Surgery, 3Histopathology, University of Oxford, Radcliffe Infirmary, Oxford OX2 6QX, UKīackgroundClinical, serological, and molecular data support the existence of discrete subsets of Crohn's disease (CD) defined by location of disease. 001 Clinical and molecular characteristics of isolated colonic Crohn's disease
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